Measurement of Ligand–Target Residence Times by 1H Relaxation Dispersion NMR Spectroscopy
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چکیده
منابع مشابه
Measurement of Ligand–Target Residence Times by 1H Relaxation Dispersion NMR Spectroscopy
A ligand-observed 1H NMR relaxation experiment is introduced for measuring the binding kinetics of low-molecular-weight compounds to their biomolecular targets. We show that this approach, which does not require any isotope labeling, is applicable to ligand-target systems involving proteins and nucleic acids of variable molecular size. The experiment is particularly useful for the systematic in...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2016
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.6b01110